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Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex. -
CHIR-99021 is a potent and selective GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusb shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusb is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusb enhances mouse and human embryonic stem cells self-renewal. Laduviglusb induces autophagy. -
Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway. -
Y-27632 dihydrochloride is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 dihydrochloride attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 dihydrochloride primes human induced pluripotent stem cells (hiPSCs) to selectively differentiate towards mesodermal lineage via epithelial-mesenchymal transition-like modulation. -
Prostaglandin E2 is a hormone-like substance that participates in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. -
R-Spondin1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing the furin-like and thrombospondin structural domains. -
Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. -
FGF-10 belongs to the subgroup of FGFs that also includes FGF-3, -7, and -22. FGF-10 is secreted by mesenchymal cells and associates with extracellular FGF-BP. It preferentially binds and activates epithelial cell FGF R2 (IIb) and interacts more weakly with FGF R1 (IIb). -
The Wnt signal transduction is essential for cell proliferation and differentiation and the self-renewal of stem cells. -
HGF, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. Human HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide.
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