bioGenous™ 小鼠胆管扩增类器官培养试剂盒是一种专为成年干细胞来源的小鼠肝胆管类器官（mLDs）设计的无血清培养基。胆管上皮的自我更新由干细胞及其前体细胞的增殖驱动。在小鼠肝胆管类器官扩增培养基中，mLDs 主要由胆管上皮细胞（cholangiocytes）组成，其特征表现为 SOX9 和 CK19 的高表达。该类器官在组织结构、细胞类型组成及自我更新动态等方面均展现出典型的胆管上皮特征，因此在研究人类肝脏发育与疾病机制方面具有重要价值。

此外，通过体外扩增胆管上皮，小鼠肝胆管类器官在再生生物学领域也具备潜在应用前景。

Product Description

bioGenous™ Mouse Liver Ductal (Expansion) Organoid Kit is a serum-free culture medium for mouse liver organoids (mLDs) derived from adult stem cells. Self-renewal of the ductal epithelium is driven by the proliferation of stem cells and their progenitors. In the mouse liver ductal organoid expansion medium, mLDs are predominantly composed of cholangiocytes, characterized by the expression of SOX9 and CK19. mLDs display hallmarks of the ductal epithelium in terms of architecture, cell type composition, and self-renewal dynamics, therefore hold great promise for studies of human liver development and disease. Mouse liver ductal organoids may also have applications in regenerative biology through ex vivo expansion of the ductal epithelia.