产品介绍

bioGenous™ 小鼠胆管类器官（分化型）培养试剂盒是一种专为成年干细胞来源的小鼠肝胆管类器官（mLDs）设计的无血清培养基。在小鼠肝胆管类器官扩增培养基中，mLDs 主要由胆管上皮细胞（cholangiocytes）组成，其特征表现为 Sox9 和 Ck19 等标志物的表达。当将扩增培养基替换为分化培养基后，mLDs 可进一步分化为肝细胞，并表达肝细胞特异性标志物，如白蛋白（Albumin）、Cyp3a11 和 Mup20。

Product Description

bioGenous™ Mouse Liver Ductal (Differentiation) Organoid Kit is a serum-free culture medium for mouse liver ductal organoids (mLDs) derived from adult stem cells. In mouse liver ductal organoids expansion medium, mLDs predominantly consist of cholangiocytes, characterized by the expression of markers such as Sox9 and Ck19. When the expansion medium is replaced with differentiation medium, mLDs can differentiate into hepatocyte cells, which exhibit hepatocyte-specific markers including Albumin, Cyp3a11, and Mup20. Mouse liver ductal organoids display hallmarks of the ductal epithelium in terms of architecture, cell type composition, and self-renewal dynamics, therefore hold great promise for studies of mouse liver development and disease.