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OrganRegen-Estradiol（C502820）

产品中心 > 类器官产品 > OrganRegen-Estradiol（C502820）

OrganRegen-Estradiol（C502820）

Estradiol
货号：C502820
规格：1g
品牌：OrganRegen

价格：￥916.00

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产品详细

Estradiol

货号：C502820

规格：1g

品牌：OrganRegen

产品介绍

DESCRIPTION

Background

Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway^[1][2][3].

技术参数

Alias	β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol雌二醇；强力求偶素
M. W t	272.38
Formula	C₁₈H₂₄O₂
CAS No	50-28-2
Storage	Powder	-20°C	3 years
		4°C	2 years
	In solvent	-80°C	6 months
		-20°C	1 month
Solubility	DMSO	≥ 100 mg/mL(283.71 mM)
	Ethanol	14 mg/mL(51.40 mM)
	H2O	< 0.1 mg/mL(insoluble)

BIOLOGICAL ALTIVITY

In Vitro

Estradiol causes new dendritic spines and synapses in hippocampal CA1 pyramidal cells. Estradiol increases NMDA receptor binding by 46% in parallel with dendritic spine and synapse density. Estradiol also elevates sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and such an effect is correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells^[1]. Estradiol reduces Ba²⁺ entry reversibly via Ca²⁺ channels in acutely dissociated and cultured neostriatal neurons. Estradiol also reduces Ba²⁺ currents but is significantly less effective than Estradiol in rat neostriatal neurons^[2].

In Vivo

Estradiol functions in hippocampal synapse density during the estrous cycle in the adult rat^[4].Estradiol reverses the ovariectomy-induced decrease in spine density. Estradiol in combination with progesterone enhances spine density for 2 to 6 h but decreases following estradiol alone^[5].Estradiol (0.2 mg/kg; i.p.; C57BL/6 female mice) plus 10 or 20 mg/kg progesterone, enhances memory consolidation in young ovariectomized mice^[6].

REFERENCES

[1]. Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49.

[2]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9.

[3]. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84.

[4]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54.

[5]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306.

[6]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.