OrganRegen-Forskolin（C665752）
OrganRegen-Forskolin（C665752）
货号：C665752
规格：50mg
品牌：OrganRegen
Forskolin
货号：C665752
规格：50mg
品牌：OrganRegen
产品介绍
DESCRIPTION
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase[1]. Forskolin is also an inducer of intracellular cAMP formation[2]. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR[3]. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy[1][2][3]. | |||
Alias | 毛喉素; Coleonol; Colforsin | ||
M. W t | 410.50 | ||
Formula | C22H34O7 | ||
CAS No | |||
Storage | Powder | -20°C | 3 years |
In solvent | -80°C | 6 months | |
-20°C | 1 month | ||
Solubility | DMSO | 100 mg/mL(243.61 mM; Need ultrasonic) | |
Ethanol | 82 mg/mL(199.76 mM) | ||
H2O | < 0.1 mg/mL(insoluble) | ||
技术参数
BIOLOGICAL ALTIVITY
Forskolin (Fsk) is a naturally occurring diterpene isolated from Coleus forskholii, directly activates adenylyl cyclase (AC) through its catalytic subunit to increase intracellular levels of cyclic adenosine monophosphate (cAMP)[1].
Forskolin (Fsk) affects the proliferation of the human T-cell lines such as Kit 225 and MT-2. Forskolin treatment inhibits the proliferation of both Kit 225 and MT-2 cells in a dose-dependent manner with an IC50 equal to ~5 μM Fsk. Forskolin treatment (10-100 μM) increases cAMPi levels ~5- to 20-fold above basal levels, which reache maximum levels between 50-100 μM Forskolin[4].
In Vivo
The Forskolin (Coleonol)-treated Mrp4-/- mice shows an increased number of Ki67-positive and cleaved caspase 3-positive ECs, a significant decrease in the amount of pericyte coverage, and a reduced number of empty sleeves. In pups exposed to hyperoxia (75% oxygen) from P7 to P12, the Mrp4-/- mice shows a significant increase in the unvascularized retinal area[2].
REFERENCES
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