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OrganRegen-Forskolin（C665752）

产品中心 > 类器官小分子 > OrganRegen-Forskolin（C665752）

OrganRegen-Forskolin（C665752）

Forskolin
货号：C665752
规格：50mg
品牌：OrganRegen

价格：￥3232.00

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规格：

50mg

产品详细

Forskolin

货号：C665752

规格：50mg

品牌：OrganRegen

产品介绍

DESCRIPTION

Background	Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase^[1]. Forskolin is also an inducer of intracellular cAMP formation^[2]. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR^[3]. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy^[1][2][3].
Alias	毛喉素; Coleonol; Colforsin
M. W t	410.50
Formula	C₂₂H₃₄O₇
CAS No	66575-29-9
Storage	Powder	-20°C	3 years
	In solvent	-80°C	6 months
		-20°C	1 month
Solubility	DMSO	100 mg/mL(243.61 mM; Need ultrasonic)
	Ethanol	82 mg/mL(199.76 mM)
	H2O	< 0.1 mg/mL(insoluble)

技术参数

BIOLOGICAL ALTIVITY

In Vitro

Forskolin (Fsk) is a naturally occurring diterpene isolated from Coleus forskholii, directly activates adenylyl cyclase (AC) through its catalytic subunit to increase intracellular levels of cyclic adenosine monophosphate (cAMP)^[1].

Forskolin (Fsk) affects the proliferation of the human T-cell lines such as Kit 225 and MT-2. Forskolin treatment inhibits the proliferation of both Kit 225 and MT-2 cells in a dose-dependent manner with an IC50 equal to ~5 μM Fsk. Forskolin treatment (10-100 μM) increases cAMPi levels ~5- to 20-fold above basal levels, which reache maximum levels between 50-100 μM Forskolin^[4].

In Vivo

The Forskolin (Coleonol)-treated Mrp4-/- mice shows an increased number of Ki67-positive and cleaved caspase 3-positive ECs, a significant decrease in the amount of pericyte coverage, and a reduced number of empty sleeves. In pups exposed to hyperoxia (75% oxygen) from P7 to P12, the Mrp4-/- mice shows a significant increase in the unvascularized retinal area^[2].

REFERENCES

[1]. Robbins JD, et al. Forskolin carbamates: binding and activation studies with type I adenylyl cyclase. J Med Chem. 1996 Jul 5;39(14):2745-52.

[2]. Matsumiya W, et al. Forskolin modifies retinal vascular development in Mrp4-knockout mice. Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8029-35.

[3]. Mayati A, et al. Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep. 2018 Oct 31;8(1):16115.

[4]. Ríos-Silva M, et al. Effect of chronic administration of forskolin on glycemia and oxidative stress in rats with and without experimental diabetes. Int J Med Sci. 2014 Mar 11;11(5):448-52.