OrganRegen A-83-01（C909910）
OrganRegen A-83-01（C909910）
货号：C909910
规格：50mg
品牌：OrganRegen
A-83-01
货号：C909910
规格：50mg
品牌：OrganRegen
产品介绍
DESCRIPTION
| |||
M. W t | 421.52 | ||
Formula | C97H124N20O31S | ||
CAS No | 10047-33-3 | ||
Storage | Powder | -20°C 3 years | |
Solubility | DMSO | 41.67 mg/mL(98.86 mM; Need ultrasonic) | |
H2O | < 0.1 mg/mL(insoluble) | ||
技术参数
BIOLOGICAL ALTIVITY
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, reduces the level of ALK-5-induced transcription with an IC50 of 12 nM in Mv1Lu cells, also blocks the ALK4-TD and ALK7-TD induced transcription with IC50s of 45 nM and 7.5 nM in R4-2 cells, and weakly suppresses that induced by constitutively active ALK-6, ALK-2, ALK-3, and ALK-1. A 83-01 (0.03-10 µM) potently prevents the growth-inhibitory effects of TGF-β, and completely inhibits the effect at 3 µM. A 83-01 (1-10 µM) inhibits TGF-β-induced Smad activation in HaCaT cells[1]. A 83-01 (1 µM) decreases cell motility, adhesion and invasion increased by TGF-β1 in HM-1 cells, but does not change cell proliferation[2].
In Vivo
A 83-01 (50, 150 and 500 μg/mouse, i.p.) significantly improves survival of the mice without body weight or neurobehavioral appearances[2]. A 83-01 (0.5 mg/kg, i.p.) shows a significantly strong antitumor effect in mice bearing M109 cells[3].
REFERENCES
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