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类器官基质胶

Organoid Culture ECM (Reduced Growth  Factor) 

产品介绍

bioGenous™ 类器官培养基质胶是一种从 Engelbreth-Holm-Swarm（EHS）小鼠肉瘤中提取并纯化的可溶性基底膜基质，主要成分包括层粘连蛋白（laminin）、IV 型胶原（collagen IV）、巢蛋白（nidogen/entactin）和硫酸乙酰肝素蛋白聚糖（heparan sulfate proteoglycan）。

本品为低生长因子型（Reduced Growth Factor, RGF）基质胶，可最大程度减少外源因子干扰，便于精确调控类器官培养微环境，提升实验重复性和数据一致性。适用于人胚胎干细胞（hESCs）、成体干细胞及各类组织来源的健康或肿瘤类器官的 3D 培养与长期维持。

该基质胶与所有常用培养基兼容，在 10°C 以上即可成胶，操作简便，是类器官、类胚体（embryoid bodies）及体内移植实验的理想支撑基质。

Product Description

Basement membranes are thin continuous layers of specialized extracellular matrices that form the interface on which epithelial, endothelial, or neuronal cells grow. Basement membranes also support muscle and Schwann cells of the peripheral nerves as they are found surrounding these cells. The bioGenous^TM Organoid Culture ECM is a soluble form of basement membrane extracted and purified from the Engelbreth-Holm-Swarm (EHS) tumor. The major constituents of the bioGenous^TM Organoid Culture ECM include laminin, collagen IV, entactin/nidogen, and heparin sulfate proteoglycan.

bioGenous^TM Organoid Culture ECM is a reduced growth factor hydrogel that allows the complete control of the organoid culture microenvironment to allow for more consistent cell growth and reproducible experiments. It supports the growth and maintenance of human embryonic stem cells (hESCs) and tissue-derived stem cells, and for the in vivo study of both healthy and tumor organoids derived from various organs. bioGenous^TM Organoid Culture ECM is compatible with all culture media and gels at temperatures above 10°C to form a reconstituted basement membrane.